Adverse effect of butyrophenone and thiothixene neuroleptics Save
ICD-10 code: T43.4X5
Chapter: Injury, poisoning and certain other consequences of external causes
Adverse Effects of Butyrophenone and Thiothixene Neuroleptics
Butyrophenone and thiothixene are two types of neuroleptic medications used in the treatment of various mental disorders. While they can be effective in managing symptoms such as hallucinations, delusions, and agitation, they also come with a range of adverse effects that patients and healthcare providers should be aware of.
- Extrapyramidal Symptoms (EPS) - Butyrophenone and thiothixene neuroleptics can cause a range of movement disorders known as extrapyramidal symptoms. These include akathisia (restlessness), dystonia (muscle spasms), parkinsonism (tremors and rigidity), and tardive dyskinesia (involuntary movements).
- Sedation and Drowsiness - These medications can also cause sedation and drowsiness, which can affect a patient's ability to perform daily activities and operate machinery.
- Anticholinergic Effects - Butyrophenone and thiothixene neuroleptics can block the action of acetylcholine, a neurotransmitter that plays a role in various physiological processes. This can lead to anticholinergic side effects such as dry mouth, blurred vision, constipation, and urinary retention.
- Cardiovascular Effects - Some studies have found that thiothixene may increase the risk of cardiovascular events such as heart attacks and strokes. Patients with pre-existing cardiovascular conditions should be monitored closely while taking these medications.
- Endocrine Effects - Butyrophenone and thiothixene neuroleptics can affect the levels of various hormones in the body, including prolactin. Increased prolactin levels can lead to side effects such as breast enlargement, menstrual irregularities, and decreased libido.
It's important for patients and healthcare providers to weigh the potential benefits of these medications against their potential adverse effects. Patients should be monitored closely for the development of EPS and other side effects, and healthcare providers should consider alternative treatments if these side effects become severe or intolerable. With proper monitoring and management, however, butyrophenone and thiothixene neuroleptics can be a useful tool in the treatment of mental disorders.