Adverse effect of glucocorticoids and synthetic analogues Save
ICD-10 code: T38.0X5
Chapter: Injury, poisoning and certain other consequences of external causes
Adverse Effects of Glucocorticoids and Synthetic Analogues
Glucocorticoids and synthetic analogues are commonly used to treat a variety of inflammatory and autoimmune conditions. However, these drugs can have adverse effects on the body when used over a long period of time. Here are some of the most common adverse effects of glucocorticoids and their synthetic analogues:
- Osteoporosis: Long-term use of glucocorticoids can lead to bone loss and increase the risk of fractures. This is because glucocorticoids suppress the production of new bone and increase the rate of bone breakdown.
- Weight gain: Glucocorticoids can cause weight gain and redistribution of fat to the face, neck, and trunk. This is because glucocorticoids increase appetite and promote fat storage.
- Diabetes: Glucocorticoids can cause insulin resistance and increase blood glucose levels. This can lead to the development of diabetes in some patients.
- Immunosuppression: Glucocorticoids suppress the immune system, leaving patients vulnerable to infections. This is because glucocorticoids inhibit the production of white blood cells, which are responsible for fighting infections.
- Cataracts: Long-term use of glucocorticoids can increase the risk of cataracts. This is because glucocorticoids can cause the lens of the eye to become cloudy and opaque.
- Mood changes: Glucocorticoids can cause mood changes, such as anxiety, depression, and irritability. This is because glucocorticoids can affect the levels of neurotransmitters in the brain.
It is important to note that the risk of adverse effects increases with the dose and duration of glucocorticoid therapy. Patients who are taking these drugs should be monitored closely by their healthcare provider and should be educated about the potential risks and benefits of these medications.
In conclusion, while glucocorticoids and synthetic analogues can be effective in treating inflammatory and autoimmune conditions, they can also have significant adverse effects on the body. Patients should work closely with their healthcare provider to manage these risks and ensure that they are receiving the appropriate treatment for their condition.