Adverse effect of mixed antiepileptics Save
ICD-10 code: T42.5X5
Chapter: Injury, poisoning and certain other consequences of external causes
Adverse effect of mixed antiepileptics
Epilepsy is a neurological disorder that affects millions of people worldwide. The condition is characterized by recurrent seizures, which are caused by abnormal electrical activity in the brain. Antiepileptic drugs (AEDs) are commonly used to manage seizures, and many patients require a combination of AEDs to achieve adequate seizure control. However, using multiple AEDs can increase the risk of adverse effects.
What are mixed antiepileptics?
Mixed antiepileptics refer to the use of two or more AEDs in combination. This approach is often used when monotherapy (the use of a single AED) is not effective in controlling seizures. A combination of AEDs can help to reduce the frequency and severity of seizures and improve quality of life for patients with epilepsy.
Adverse effects of mixed antiepileptics
Increased risk of drug interactions: When two or more AEDs are used together, there is a higher risk of drug interactions. This can lead to changes in drug levels in the blood, which can affect seizure control and increase the risk of side effects.
Increased risk of cognitive impairment: Some studies have suggested that the use of multiple AEDs can lead to cognitive impairment, particularly in older adults. This can include problems with memory, attention, and executive function.
Increased risk of birth defects: Women who take mixed antiepileptics during pregnancy have a higher risk of having a child with birth defects. This is particularly true for certain AEDs, such as valproic acid.
Increased risk of liver damage: Some AEDs can cause liver damage, and the risk may be increased when two or more drugs are used together. Patients taking mixed antiepileptics should have regular liver function tests to monitor for potential damage.
Increased risk of skin reactions: Some AEDs can cause skin reactions, such as rash and Stevens-Johnson syndrome. The risk may be higher when multiple drugs are used together.
Conclusion
Mixed antiepileptics can be an effective way to manage seizures in patients with epilepsy. However, this approach can also increase the risk of adverse effects, including drug interactions, cognitive impairment, birth defects, liver damage, and skin reactions. Patients and healthcare providers should carefully weigh the benefits and risks of using multiple AEDs and monitor for potential adverse effects.