Amyloidosis, unspecified digital illustration

Amyloidosis, unspecified Save

ICD-10 code: E85.9

Chapter: Endocrine, nutritional and metabolic diseases

Amyloidosis, Unspecified: A Condition You Need to Know

Amyloidosis is a rare disease that occurs when abnormal proteins called amyloid build up in the body's organs and tissues. The condition can affect different organs, including the heart, kidneys, liver, and nerves, and can lead to serious complications.

There are several types of amyloidosis, each caused by a different abnormal protein. The most common types are AL amyloidosis, which occurs when abnormal antibodies produced by plasma cells build up in the body, and ATTR amyloidosis, which occurs when a protein called transthyretin misfolds and builds up in the body.

However, there is also a type of amyloidosis called "unspecified amyloidosis," which means that the specific type of amyloid protein causing the disease is unknown. This type of amyloidosis is less common than AL or ATTR amyloidosis, but it still poses a significant health risk to affected individuals.

Symptoms of Unspecified Amyloidosis

The symptoms of unspecified amyloidosis can vary depending on which organs are affected. Some common symptoms include:

  1. Fatigue and weakness
  2. Weight loss
  3. Swelling in the legs and feet
  4. Shortness of breath
  5. Numbness or tingling in the hands and feet
  6. Diarrhea or constipation
  7. Enlarged tongue

It's important to note that these symptoms can also be caused by other conditions, so it's essential to see a doctor if you experience any of them.

Diagnosis and Treatment

Diagnosing unspecified amyloidosis can be challenging because the specific type of amyloid protein causing the disease is unknown. Doctors will typically perform a series of tests, including blood tests, urine tests, imaging tests, and biopsies, to identify the presence of amyloid deposits in the body's tissues and organs.

The treatment of unspecified amyloidosis depends on the severity of the disease and which organs are affected. Treatments may include medications to reduce the production of abnormal proteins, chemotherapy to destroy plasma cells that produce abnormal antibodies, or organ transplantation to replace damaged organs.


Amyloidosis, unspecified is a rare and potentially life-threatening disease that can affect multiple organs in the body. If you experience any symptoms associated with amyloidosis, it's essential to see a doctor immediately to receive a proper diagnosis and appropriate treatment to prevent further complications.

Diagnosis Codes for Amyloidosis, unspecified | E85.9