Anaplastic large cell lymphoma, ALK-negative digital illustration

Anaplastic large cell lymphoma, ALK-negative Save

ICD-10 code: C84.7

Chapter: Neoplasms

Anaplastic large cell lymphoma, ALK-negative

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma that occurs when white blood cells called T-cells become abnormal and grow uncontrollably. ALCL can be divided into two subtypes based on the presence or absence of a specific genetic mutation called anaplastic lymphoma kinase (ALK).

The ALK-negative subtype of ALCL is less common than the ALK-positive subtype, accounting for about 20% of all ALCL cases. It tends to occur in older adults and has a more aggressive course than ALK-positive ALCL.

Common symptoms of ALK-negative ALCL include swollen lymph nodes, fever, night sweats, weight loss, and fatigue. However, these symptoms can also be caused by other conditions, so it is important to undergo diagnostic tests to confirm the diagnosis.

Diagnosis of ALK-negative ALCL typically involves a combination of imaging tests, such as CT scans and PET scans, and a biopsy of the affected tissue. The biopsy is used to examine the cells under a microscope and determine if they are abnormal T-cells.

Treatment for ALK-negative ALCL typically involves chemotherapy, radiation therapy, and/or stem cell transplantation. The specific treatment plan depends on the extent and severity of the disease, as well as the patient’s overall health.

  1. Chemotherapy: This involves the use of drugs to kill cancer cells. The drugs are typically given intravenously and may be administered in cycles over several months.
  2. Radiation therapy: This involves the use of high-energy radiation beams to kill cancer cells. It is often used in combination with chemotherapy.
  3. Stem cell transplantation: This involves the transplantation of healthy stem cells to replace damaged or destroyed bone marrow. It may be used in patients with more advanced or aggressive disease.

Overall, the prognosis for ALK-negative ALCL varies depending on the extent and severity of the disease at the time of diagnosis. However, with early detection and appropriate treatment, many patients are able to achieve remission and live long, healthy lives.