Breakdown (mechanical) of artificial skin graft and decellularized allodermis Save

What is a Breakdown (Mechanical) of Artificial Skin Graft and Decellularized Allodermis?

Artificial skin grafts and decellularized allodermis are two types of skin substitutes used in wound healing. They are designed to replace damaged or lost skin and promote tissue regeneration. However, sometimes these substitutes may break down mechanically, leading to complications. Let's take a closer look at this phenomenon.

What causes the breakdown of artificial skin grafts and decellularized allodermis?

The breakdown of these skin substitutes can occur due to various reasons. One of the main reasons is mechanical stress. When the graft is under tension or pressure, it can cause the material to break down. The breakdown can also be caused by the use of inappropriate fixation techniques or sutures that are too tight. Another cause of breakdown is the presence of bacteria or other contaminants that can cause infection.

What are the signs of a breakdown?

The signs of a breakdown can vary depending on the severity of the problem. One of the first signs of a breakdown is a change in the color or texture of the graft. It may become discolored, wrinkled, or rough to the touch. In more severe cases, the graft may start to break down completely, leading to an open wound.

How can a breakdown be prevented?

Preventing a breakdown is crucial to the success of the skin graft. The first step is to ensure that the graft is properly secured and not under too much tension or pressure. The use of appropriate fixation techniques and sutures is essential. Additionally, it is important to maintain a sterile environment to prevent infection. Finally, regular monitoring of the graft is necessary to detect any signs of breakdown early on.

Conclusion

The breakdown of artificial skin grafts and decellularized allodermis can be a serious complication that can delay wound healing and lead to further problems. However, with proper care and monitoring, it is possible to prevent this from happening. If you suspect that your skin graft is breaking down, it is important to seek medical attention immediately.

1. Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277632/
2. Source: https://jamanetwork.com/journals/jamasurgery/fullarticle/186950