Cutaneous follicle center lymphoma digital illustration

Cutaneous follicle center lymphoma Save

ICD-10 code: C82.6

Chapter: Neoplasms

Understanding Cutaneous Follicle Center Lymphoma

Cutaneous follicle center lymphoma (CFCL) is a rare type of non-Hodgkin lymphoma that affects the skin. It is a slow-growing cancer that develops from B-cells in the lymphatic system. The lymphatic system is a network of tissues and organs that help fight infections and other diseases.

CFCL typically affects middle-aged and older adults, and it is more common in women than men. The exact cause of CFCL is unknown, but it is believed to be linked to genetic mutations.


The symptoms of CFCL can vary from person to person, but common signs include:

  1. One or more raised, reddish-brown nodules on the skin
  2. Increased skin pigmentation
  3. Itching and burning sensations
  4. Blisters and ulcers

These symptoms can also be indicative of other skin conditions, which is why it is important to see a dermatologist for an accurate diagnosis.


CFCL is a slow-growing cancer, and it may not require treatment immediately. However, treatment may be necessary if the cancer is causing discomfort or disfigurement, or if it is spreading to other parts of the body.

The most common treatments for CFCL include:

  1. Topical corticosteroids
  2. Phototherapy
  3. Chemotherapy
  4. Radiation therapy

Your dermatologist will determine the best course of treatment based on the severity of your condition and your overall health.


While CFCL is a rare form of non-Hodgkin lymphoma, it is important to be aware of the symptoms and seek medical attention if you suspect that you may have it. With early diagnosis and treatment, the outlook for CFCL is generally favorable.