Disorders of tryptophan metabolism Save
ICD-10 code: E70.5
Chapter: Endocrine, nutritional and metabolic diseases
Understanding Disorders of Tryptophan Metabolism
Tryptophan is an essential amino acid that is vital for the body’s growth and development. It plays a crucial role in the synthesis of proteins, niacin, and serotonin. However, the metabolism of tryptophan can be disrupted leading to various disorders.
- Tryptophan malabsorption syndrome: This disorder is characterized by the inability of the body to absorb tryptophan from the diet. The condition causes low levels of tryptophan in the blood, leading to fatigue, depression, and anxiety.
- Tryptophan hydroxylase deficiency: This disorder is a rare genetic condition that causes a deficiency of the enzyme tryptophan hydroxylase. This enzyme is responsible for converting tryptophan to serotonin. Low levels of serotonin lead to mood disorders, including depression and anxiety.
- Hartnup disease: This is another rare genetic disorder that affects the absorption of tryptophan. The condition causes skin rashes, neurological symptoms, and psychiatric disorders.
- Carboxylase deficiency: This disorder is caused by a deficiency of the enzyme tryptophan 2,3-dioxygenase, which is responsible for the metabolism of tryptophan. The condition leads to high levels of tryptophan in the blood, causing neurological symptoms and psychiatric disorders.
Diagnosis of disorders of tryptophan metabolism typically involves a blood test to measure levels of tryptophan and other amino acids. Treatment options vary depending on the specific disorder but may include dietary changes, supplements, and medications.
It is essential to consult a healthcare professional if you suspect you have a disorder of tryptophan metabolism. Early diagnosis and treatment can help manage symptoms and improve quality of life.
Conclusion
Disorders of tryptophan metabolism can have significant impacts on an individual’s physical and mental health. Understanding the symptoms and causes of these disorders is critical to early diagnosis and management. Consultation with a healthcare professional is necessary for proper diagnosis and treatment of these disorders.