Disorders resulting from impaired renal tubular function Save

Disorders Resulting from Impaired Renal Tubular Function

Impaired renal tubular function can result in various disorders that affect the body's ability to regulate electrolytes, acid-base balance, and fluid volume. The renal tubules are responsible for reabsorbing essential substances such as sodium, potassium, bicarbonate, and glucose while excreting waste products such as urea and creatinine. When the renal tubular function is impaired, these processes are disrupted, leading to several disorders.

1. Fanconi syndrome: This is a disorder that affects the proximal renal tubules, which are responsible for reabsorbing glucose, amino acids, bicarbonate, and phosphate. In Fanconi syndrome, there is excessive excretion of these substances in the urine, leading to metabolic acidosis, hypokalemia, and hypophosphatemia. Symptoms may include polyuria, dehydration, and bone deformities.
2. Bartter syndrome: This is a rare genetic disorder that affects the thick ascending limb of the loop of Henle, where sodium, potassium, and chloride are reabsorbed. In Bartter syndrome, there is excessive excretion of these electrolytes in the urine, leading to hypokalemia, metabolic alkalosis, and increased urine volume. Symptoms may include muscle weakness, fatigue, and growth retardation.
3. Gitelman syndrome: This is a rare genetic disorder that affects the distal convoluted tubules, where sodium, chloride, and magnesium are reabsorbed. In Gitelman syndrome, there is excessive excretion of these electrolytes in the urine, leading to hypokalemia, metabolic alkalosis, and hypomagnesemia. Symptoms may include muscle weakness, cramps, and fatigue.
4. Nephrogenic diabetes insipidus: This is a disorder that affects the collecting ducts, where water is reabsorbed. In nephrogenic diabetes insipidus, there is impaired response to antidiuretic hormone (ADH), leading to excessive urine output and dehydration. Symptoms may include polyuria, nocturia, and thirst.
5. Renal tubular acidosis: This is a disorder that affects the renal tubules' ability to maintain acid-base balance. There are three types of renal tubular acidosis: type 1 (distal RTA), type 2 (proximal RTA), and type 4 (hyperkalemic RTA). In type 1 RTA, there is impaired secretion of hydrogen ions, leading to metabolic acidosis. In type 2 RTA, there is impaired reabsorption of bicarbonate, leading to metabolic acidosis. In type 4

   Diagnosis Codes for Disorders resulting from impaired renal tubular function | N25

   • N25.0, Renal osteodystrophy
   • N25.1, Nephrogenic diabetes insipidus

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