Mast cell activation syndrome and related disorders digital illustration

Mast cell activation syndrome and related disorders Save

ICD-10 code: D89.4

Chapter: Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism

Mast Cell Activation Syndrome and Related Disorders

Mast cell activation syndrome (MCAS) is a condition where mast cells in the body become overactive and release excessive amounts of histamine and other mediators. This can lead to a range of symptoms including allergic reactions, gastrointestinal issues, and neurological problems. MCAS is a relatively new diagnosis and is often considered an umbrella term for a range of related disorders.

MCAS can be difficult to diagnose as symptoms can vary widely from person to person. However, some common symptoms include hives, itching, flushing, abdominal pain, and headaches. Other symptoms may include brain fog, anxiety, and fatigue.

There is currently no cure for MCAS, but there are treatment options that can help manage symptoms. These may include antihistamines, mast cell stabilizers, and dietary changes. It is also important to avoid triggers that can exacerbate symptoms, such as certain foods, medications, and stress.

Related Disorders

There are several related disorders that are often grouped under the umbrella term of MCAS. These include:

  1. Mastocytosis: This is a rare disorder where there is an abnormal accumulation of mast cells in the body. Mastocytosis can be systemic or localized, and symptoms can range from mild to severe.
  2. Ehlers-Danlos Syndrome: This is a genetic disorder that affects the connective tissue in the body. People with Ehlers-Danlos Syndrome may have hypermobile joints, skin that bruises easily, and other symptoms.
  3. Postural Orthostatic Tachycardia Syndrome (POTS): This is a condition where there is an abnormal increase in heart rate upon standing. People with POTS may also experience dizziness, fatigue, and other symptoms.

While these disorders are distinct, they share some common features with MCAS. For example, they may all involve dysregulation of the autonomic nervous system, which can lead to a range of symptoms across multiple organ systems.

If you are experiencing symptoms of MCAS or a related disorder, it is important to speak with a healthcare professional. They can help determine the underlying cause of your symptoms and develop a treatment plan that works for you.