Mucopolysaccharidosis, type I digital illustration

Mucopolysaccharidosis, type I Save


ICD-10 code: E76.0

Chapter: Endocrine, nutritional and metabolic diseases

Mucopolysaccharidosis, type I: Understanding the Rare Genetic Disorder

Mucopolysaccharidosis, type I (MPS I) is a rare genetic disorder that affects the body's ability to break down complex sugars, leading to the accumulation of these substances in various organs and tissues. It is caused by a deficiency in the enzyme alpha-L-iduronidase, which is responsible for breaking down glycosaminoglycans (GAGs) in the body.

The incidence of MPS I is estimated to be around 1 in 100,000 births, making it a rare disease. The symptoms of MPS I can vary widely depending on the severity of the disease and the organs and tissues affected by the accumulation of GAGs. Some of the common symptoms of MPS I include facial abnormalities, skeletal deformities, hearing loss, heart problems, and developmental delays.

Types of MPS I

There are three types of MPS I, which are distinguished by the severity of the disease and the age at which symptoms appear:

  1. Hurler syndrome: This is the most severe form of MPS I, and symptoms usually appear within the first year of life. Children with Hurler syndrome often have a shortened lifespan and may require a bone marrow transplant to improve their prognosis.
  2. Scheie syndrome: This is the mildest form of MPS I, and symptoms may not appear until later in life. Individuals with Scheie syndrome may have a near-normal lifespan, but may still experience some health problems related to the accumulation of GAGs.
  3. Hurler-Scheie syndrome: This form of MPS I is intermediate in severity between Hurler and Scheie syndromes, and symptoms may appear in childhood or adolescence.
Treatment and Management of MPS I

Currently, there is no cure for MPS I, and treatment is focused on managing the symptoms of the disease. Enzyme replacement therapy (ERT) is a treatment option for some forms of MPS I, which involves giving the patient regular infusions of the missing enzyme alpha-L-iduronidase. This can help to reduce the accumulation of GAGs and improve some of the symptoms of the disease.

In addition to ERT, other treatments for MPS I may include surgery to correct skeletal deformities, hearing aids or cochlear implants to address hearing loss, and heart surgery to correct cardiac abnormalities. It is important for individuals with MPS I to receive ongoing medical care from a team of specialists, including geneticists, pediatricians, and other healthcare providers.

Conclusion

Mucopolysaccharidosis, type I is a rare genetic disorder that can have a significant impact on a person's health