Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints, causing inflammation and pain. One type of RA is known as other rheumatoid arthritis with rheumatoid factor, or seronegative rheumatoid arthritis. This type of RA is diagnosed when a patient has symptoms of RA but does not test positive for rheumatoid factor (RF).
RF is an antibody that is present in the blood of many people with RA. However, some patients with RA do not produce RF, which can make it difficult to diagnose the disease. In these cases, doctors may use other tests, such as testing for anti-cyclic citrullinated peptide (anti-CCP) antibodies, to confirm a diagnosis of RA.
Other rheumatoid arthritis with rheumatoid factor has similar symptoms to typical RA, including joint pain, swelling, and stiffness. However, it is often less severe and progresses more slowly than RA that is positive for RF. Additionally, patients with seronegative RA may have more joint involvement outside of the hands and feet, such as in the spine.
It is important for patients with other rheumatoid arthritis with rheumatoid factor to work closely with their doctors to manage their symptoms and prevent joint damage. By taking a comprehensive approach that includes medication, exercise, and a healthy diet, patients can live a full and active life despite their diagnosis.