Poisoning by anticholinesterase agents, intentional self-harm digital illustration

Poisoning by anticholinesterase agents, intentional self-harm Save


ICD-10 code: T44.0X2

Chapter: Injury, poisoning and certain other consequences of external causes

Poisoning by Anticholinesterase Agents: Intentional Self-Harm

Anticholinesterase agents are a group of chemicals that inhibit the activity of the enzyme acetylcholinesterase. This enzyme is responsible for breaking down the neurotransmitter acetylcholine, which is important for the proper functioning of the nervous system. Anticholinesterase agents are used in a variety of contexts, including as insecticides and as medications for the treatment of conditions such as Alzheimer's disease and myasthenia gravis.

However, when these agents are ingested in large quantities or inappropriately, they can cause serious harm to the body. One of the most common causes of poisoning by anticholinesterase agents is intentional self-harm.

  1. Symptoms of anticholinesterase poisoning
  2. The symptoms of anticholinesterase poisoning can vary depending on the specific agent involved, but may include:

    • Nausea and vomiting
    • Abdominal pain
    • Diarrhea
    • Blurred vision
    • Miosis (constriction of the pupils)
    • Excessive sweating
    • Weakness and fatigue
    • Respiratory distress

    In severe cases, anticholinesterase poisoning can lead to seizures, coma, and even death.

  3. Treatment for anticholinesterase poisoning
  4. If you or someone you know has been poisoned by an anticholinesterase agent, it is important to seek medical attention immediately. Treatment for anticholinesterase poisoning may include:

    • Decontamination to remove any remaining poison from the body
    • Administration of atropine to counteract the effects of the poison
    • Supportive care, such as oxygen therapy and intravenous fluids, to help manage symptoms
    • In severe cases, treatment may also involve the use of pralidoxime, a medication that can reactivate acetylcholinesterase and help to reverse the effects of the poison
  5. Prevention of anticholinesterase poisoning
  6. The best way to prevent poisoning by anticholinesterase agents is to use these chemicals only as directed. If you work with these agents, be sure to follow all safety precautions and wear appropriate protective gear. If you are taking a medication that contains an anticholinesterase agent,