Solitary plasmacytoma digital illustration

Solitary plasmacytoma Save

ICD-10 code: C90.3

Chapter: Neoplasms

Solitary Plasmacytoma: A Rare Cancer of the Plasma Cells

Solitary plasmacytoma is a rare form of cancer that affects plasma cells, a type of white blood cell responsible for producing antibodies that help fight infections. Unlike multiple myeloma, which is a cancer that affects multiple plasma cells throughout the body, solitary plasmacytoma usually affects only one area of the body, commonly the bone or soft tissue.

Although it is a rare cancer, solitary plasmacytoma can still be a serious condition that requires prompt diagnosis and treatment. Here is what you need to know about the symptoms, diagnosis, and treatment of solitary plasmacytoma.

Symptoms of Solitary Plasmacytoma

The symptoms of solitary plasmacytoma vary depending on the location of the tumor. If the tumor is in the bone, the most common symptoms include:

  1. Pain in the affected bone
  2. Weakness or numbness in the affected area
  3. Frequent fractures or bone breaks

If the tumor is in the soft tissue, the symptoms may include:

  1. Lump or swelling in the affected area
  2. Pain or discomfort
  3. Numbness or weakness
Diagnosis of Solitary Plasmacytoma

Diagnosing solitary plasmacytoma usually involves a combination of imaging tests, blood tests, and a biopsy. Imaging tests such as X-rays, CT scans, and MRI scans can help identify the location and size of the tumor. Blood tests can help detect abnormal levels of immunoglobulins, a type of antibody produced by plasma cells. A biopsy, which involves removing a sample of tissue from the tumor, is necessary to confirm the diagnosis.

Treatment of Solitary Plasmacytoma

The treatment for solitary plasmacytoma usually involves radiation therapy and/or surgery. Radiation therapy uses high-energy X-rays or other types of radiation to kill cancer cells and shrink the tumor. Surgery may be necessary to remove the tumor if it is causing significant pain or impairing function.

After treatment, regular follow-up appointments and imaging tests are necessary to monitor for any signs of recurrence. In some cases, solitary plasmacytoma may progress to multiple myeloma, which is a more serious condition that requires different treatment.


Solitary plasmacytoma is a rare but serious cancer that requires prompt diagnosis and treatment. If you experience any of the symptoms listed above, talk to your doctor right away. With early detection