Acquired von Willebrand disease Save

Understanding Acquired von Willebrand Disease

Acquired von Willebrand Disease (AVWD) is a rare bleeding disorder that affects the blood's ability to clot. This condition is caused by the lack of a protein called von Willebrand Factor (VWF) in the blood plasma, which is necessary to form clots.

AVWD is different from the inherited form of von Willebrand Disease (VWD), which is passed down from parents to children through their genes. Instead, AVWD is acquired later in life due to certain medical conditions or medications that affect the production or function of VWF in the body.

1. Medical conditions: AVWD can occur in people with an underlying medical condition, such as an autoimmune disorder, cancer, or hypothyroidism. These conditions can affect the body's ability to produce or regulate VWF, leading to bleeding symptoms.
2. Medications: Certain medications, such as valproic acid, can interfere with the body's production of VWF. Other medications, such as aspirin or blood thinners, can affect the function of VWF in the blood, making it less effective in forming clots.

The symptoms of AVWD can vary depending on the severity of the condition and the underlying cause. Some common symptoms may include:

• Excessive bleeding from cuts or injuries
• Heavy or prolonged menstrual bleeding
• Bruising easily
• Bleeding into joints or muscles
• Bleeding after dental procedures or surgery

If you are experiencing any of these symptoms, it is important to speak with your healthcare provider. They can perform a series of tests to diagnose AVWD and determine the underlying cause.

While there is no cure for AVWD, there are treatments available to manage the symptoms and prevent bleeding complications. These may include medications to increase the levels of VWF in the blood or to help the blood clot more effectively. In some cases, transfusions of VWF-containing blood products may be necessary.

With proper diagnosis and management, people with AVWD can lead healthy and active lives. It is important to work closely with your healthcare provider to develop a treatment plan that is tailored to your individual needs.