Acute on chronic graft-versus-host disease Save
ICD-10 code: D89.812
Disease category: D89.81: Graft-versus-host disease
Understanding Acute on Chronic Graft-Versus-Host Disease
Acute on Chronic Graft-Versus-Host Disease (aGVHD) is a serious medical condition that occurs in patients who have undergone a stem cell transplant. It is a result of the donor cells attacking the recipient’s cells, and it can lead to severe complications and even death.
There are two types of GVHD: Acute GVHD and Chronic GVHD. The acute form typically occurs within the first 100 days following the transplant, while the chronic form can develop several months or years after the procedure.
aGVHD is the result of the chronic form worsening to a more acute stage and can occur in both acute and chronic GVHD patients.
Symptoms of Acute on Chronic Graft-Versus-Host Disease
The symptoms of aGVHD are similar to those of chronic GVHD, but they tend to be more severe and can appear suddenly. These symptoms can range from mild to severe and can include:
- Skin rash or blisters
- Abdominal pain and diarrhea
- Jaundice
- Shortness of breath
- Mouth ulcers
- Eye irritation
It is important to recognize these symptoms early as prompt diagnosis and treatment can help prevent further complications.
Causes of Acute on Chronic Graft-Versus-Host Disease
The exact cause of aGVHD is not fully understood, but it is believed to be related to the donor cells attacking the recipient’s cells. This attack can cause inflammation and damage to various organs and tissues in the body, leading to the symptoms mentioned above.
Several risk factors can increase the likelihood of developing aGVHD, including age, type of transplant, and the number of donor cells.
Conclusion
Acute on Chronic Graft-Versus-Host Disease is a severe medical condition that can occur in patients who have undergone a stem cell transplant. It is crucial to recognize the symptoms early and seek prompt medical attention to prevent further complications. Understanding the causes and risk factors associated with aGVHD can help patients and their families make informed decisions about their treatment options.
Treatment of Acute on chronic graft-versus-host disease:
Acute on Chronic Graft-Versus-Host Disease: Treatment Options
Acute on chronic graft-versus-host disease (aGVHD) is a serious post-transplant complication that occurs when the donor cells attack the recipient's body. This condition is often challenging to treat, and patients require immediate medical attention to prevent further complications.