Castleman disease, also known as Castleman syndrome or angiofollicular lymph node hyperplasia, is a rare condition that affects the lymph nodes and related tissues. Named after the American pathologist Benjamin Castleman, who first described it in the 1950s, this disease has various subtypes, including unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD).
In UCD, the disease is localized and affects a single lymph node region, while MCD involves multiple lymph nodes throughout the body. Although the exact cause of Castleman disease is unknown, it is believed to be related to an abnormal immune system response.
Castleman disease primarily affects adults, although it can also occur in children. It is more common in males than females, with most cases diagnosed between the ages of 30 and 40. The symptoms vary depending on whether it is unicentric or multicentric:
Castleman disease is often diagnosed through a combination of physical examination, imaging tests, and lymph node biopsy. It is crucial to differentiate between the unicentric and multicentric forms, as the treatment approaches and prognosis differ significantly.
While the cause of Castleman disease remains unknown, ongoing research aims to better understand this condition and develop effective treatment options.
Castleman disease, also known as Castleman's syndrome or angiofollicular lymph node hyperplasia, is a rare and complex disorder of the lymph nodes. It is characterized by abnormal growth of lymphocytes, a type of white blood cell, in the lymph nodes. The disease can affect people of all ages, but it is more commonly diagnosed in adults.
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