Cystic fibrosis with other intestinal manifestations Save

Cystic fibrosis (CF) is a genetic disorder that primarily affects the lungs and digestive system. However, in some cases, CF can also manifest with other intestinal symptoms, including meconium ileus, distal intestinal obstruction syndrome (DIOS), and rectal prolapse.

Meconium ileus is a common intestinal complication in newborns with CF. It occurs when the thick, sticky meconium stool obstructs the intestine, leading to abdominal distension, vomiting, and failure to pass meconium. This condition requires prompt treatment with rectal irrigations and surgery in severe cases.

DIOS is another intestinal complication that occurs in older children and adults with CF. It is caused by the accumulation of thick mucus in the distal small intestine and colon, leading to partial or complete bowel obstruction. Symptoms include severe abdominal pain, bloating, nausea, and vomiting. Treatment options include bowel rest, hydration, laxatives, and enemas.

Rectal prolapse is another intestinal manifestation of CF that occurs due to the weakening of the rectal muscles. It results in the protrusion of the rectal tissue through the anus, causing pain, bleeding, and fecal incontinence. Treatment options include surgical repair and medical management with fiber supplements, stool softeners, and bowel training.

In addition to these intestinal manifestations, CF can also lead to malabsorption of nutrients, including fat, vitamins, and minerals. This can result in growth failure, malnutrition, and osteoporosis. Treatment options include pancreatic enzyme replacement therapy, fat-soluble vitamin supplements, and calcium and vitamin D supplements.

In conclusion, while CF is primarily known for its pulmonary complications, it can also manifest with various intestinal symptoms, including meconium ileus, DIOS, rectal prolapse, and malabsorption. Early recognition and management of these complications can significantly improve the quality of life and outcomes for individuals with CF.