Drug-induced chronic gout, left knee, with tophus (tophi) Save

Drug-induced Chronic Gout, Left Knee, with Tophus (Tophi)

Gout is a form of arthritis that occurs when uric acid builds up in the body, leading to the formation of urate crystals in joints and tissues. While it is typically associated with lifestyle factors and diet, certain drugs can also trigger gout attacks. One common manifestation of drug-induced chronic gout is the development of tophi in the left knee.

Tophus:

A tophus (plural: tophi) is a deposit of urate crystals that forms around joints and other tissues. It usually appears as a firm, nodular mass under the skin. In the case of drug-induced chronic gout, tophi can develop in the left knee due to the medication's impact on uric acid levels.

Symptoms:

Individuals with drug-induced chronic gout may experience various symptoms related to the presence of tophi in the left knee. These symptoms can include pain, swelling, redness, and limited mobility in the affected joint. Additionally, tophi can sometimes burst through the skin, leading to the formation of draining sinuses.

Causes:

1. Medications: Certain drugs can increase uric acid levels or impair its excretion, leading to gout attacks. These drugs include diuretics, cyclosporine, niacin, and low-dose aspirin.
2. Underlying conditions: Individuals with existing health conditions, such as kidney disease or diabetes, may be more susceptible to drug-induced chronic gout.
3. Genetic factors: Some individuals may have a genetic predisposition that makes them more prone to developing gout, even when taking medications.

Diagnosis:

Diagnosing drug-induced chronic gout with tophi in the left knee involves a combination of medical history, physical examination, and laboratory tests. The doctor may perform joint aspiration to examine the synovial fluid for the presence of urate crystals, which is a definitive diagnostic method.

In conclusion, drug-induced chronic gout can lead to the development of tophi in the left knee. Tophi are nodular masses of urate crystals that can cause pain, swelling, and limited mobility in the affected joint. It is essential to identify the underlying cause and manage gout effectively to prevent further complications. However, the focus of this article was to provide information about drug-induced chronic gout with tophus in the left knee, without discussing treatment options.