Follicular lymphoma grade IIIb, extranodal and solid organ sites Save

Follicular Lymphoma Grade IIIb: Understanding Extranodal and Solid Organ Sites

Follicular lymphoma grade IIIb is a rare subtype of follicular lymphoma, which is characterized by the presence of large cells and a high proliferation rate. This subtype is often associated with extranodal and solid organ involvement, which can make diagnosis and management more challenging.

Extranodal involvement refers to the spread of lymphoma to tissues and organs outside of the lymphatic system, while solid organ involvement refers to the spread of lymphoma to organs such as the liver, lungs, and kidneys. In follicular lymphoma grade IIIb, extranodal and solid organ involvement is more frequent and extensive than in other subtypes of follicular lymphoma.

Common sites of extranodal involvement in follicular lymphoma grade IIIb include the bone marrow, gastrointestinal tract, skin, and central nervous system. Solid organ involvement is less common, but can occur in the liver, lungs, and kidneys.

Diagnosis of follicular lymphoma grade IIIb with extranodal and solid organ involvement typically requires a combination of imaging studies, such as CT scans and PET scans, as well as biopsies of affected tissues. In some cases, a bone marrow biopsy may also be necessary to determine the extent of involvement.

Management of follicular lymphoma grade IIIb with extranodal and solid organ involvement can be challenging, as these sites may not respond as well to standard treatments, such as chemotherapy and radiation therapy. However, there are emerging treatment options, such as immunotherapy and targeted therapy, that may be effective in these cases.

Conclusion

Follicular lymphoma grade IIIb with extranodal and solid organ involvement is a rare subtype of follicular lymphoma that can present unique diagnostic and management challenges. However, with advances in imaging and treatment options, patients with this subtype can receive effective care and management.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273296/
2. https://www.cancer.gov/types/lymphoma/hp/follicular-lymphoma-treatment-pdq
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073413/