Iatrogenic carnitine deficiency Save

Iatrogenic Carnitine Deficiency: Causes, Symptoms, and Prevention

Iatrogenic carnitine deficiency is a condition that occurs when a patient experiences a decrease in the level of carnitine in their body due to medical treatment. Carnitine is a nutrient that plays a vital role in the metabolism of fats and carbohydrates. It is naturally produced by the liver and kidneys, and it is also found in certain foods such as red meat and dairy products.

When a patient undergoes medical treatment, they may experience a decrease in the level of carnitine in their body. This can occur due to the use of certain medications, such as valproic acid, which is used to treat seizures. Valproic acid has been shown to decrease the level of carnitine in the body, leading to a deficiency.

Other medications that can cause iatrogenic carnitine deficiency include antibiotics, such as pivalic acid-containing antibiotics, and chemotherapeutic agents used in cancer treatment. Patients who undergo dialysis may also experience a decrease in carnitine levels due to the removal of the nutrient during the dialysis process.

Patients with iatrogenic carnitine deficiency may experience symptoms such as muscle weakness, fatigue, and difficulty exercising. They may also experience an increase in muscle breakdown, leading to the release of muscle enzymes into the bloodstream.

1. Causes of iatrogenic carnitine deficiency:
• Valproic acid
• Pivalic acid-containing antibiotics
• Chemotherapeutic agents used in cancer treatment
• Dialysis

Prevention of iatrogenic carnitine deficiency involves monitoring carnitine levels in patients who are being treated with medications known to cause a decrease in the nutrient. Patients may also be given carnitine supplements to prevent a deficiency from occurring.

In conclusion, iatrogenic carnitine deficiency is a condition that can occur when a patient undergoes medical treatment. It is important for healthcare providers to monitor carnitine levels in patients who are being treated with medications known to cause a decrease in the nutrient. With proper monitoring and supplementation, iatrogenic carnitine deficiency can be prevented.