Mixed cellularity Hodgkin lymphoma, spleen Save

Mixed Cellularity Hodgkin Lymphoma and its Relation to the Spleen

Mixed cellularity Hodgkin lymphoma (MCHL) is a subtype of Hodgkin lymphoma, a cancer that affects the lymphatic system. MCHL accounts for about 20-25% of all Hodgkin lymphoma cases, and it is usually diagnosed in people between the ages of 15 and 45 years old. MCHL is characterized by the presence of large, abnormal cells called Reed-Sternberg cells, which are found in lymph nodes and other parts of the body.

The spleen is an important organ in the lymphatic system, and it plays a key role in the immune response to infections. It is located in the upper left part of the abdomen, and it is responsible for filtering blood and removing old or damaged red blood cells. In some cases, MCHL can involve the spleen, which can lead to a number of symptoms and complications.

1. Enlargement of the spleen: When MCHL affects the spleen, it can cause the organ to become enlarged. This can lead to abdominal pain, bloating, and discomfort.
2. Anemia: MCHL can also lead to a decrease in the number of red blood cells in the body, which can cause anemia. Symptoms of anemia include fatigue, weakness, and shortness of breath.
3. Infections: The spleen plays an important role in fighting infections, and when it is affected by MCHL, it can lead to an increased risk of infections. This is because the spleen is responsible for filtering out bacteria and other harmful substances from the blood.

Diagnosing MCHL involving the spleen may involve imaging tests such as CT scans or PET scans, as well as a biopsy of the spleen. Treatment for MCHL may involve chemotherapy, radiation therapy, or a combination of both. In some cases, a bone marrow transplant may be necessary.

Mixed cellularity Hodgkin lymphoma is a subtype of Hodgkin lymphoma that can involve the spleen. When the spleen is affected by MCHL, it can lead to a number of symptoms and complications, including enlargement of the spleen, anemia, and an increased risk of infections. Diagnosis may involve imaging tests and a biopsy of the spleen, while treatment may involve chemotherapy, radiation therapy, or a bone marrow transplant.