Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] Save

What is Paroxysmal Nocturnal Hemoglobinuria [Marchiafava-Micheli]?

Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] is a rare and life-threatening disorder that affects the blood. It is characterized by the destruction of red blood cells, leading to anemia, blood clots, and other complications.

Symptoms of Paroxysmal Nocturnal Hemoglobinuria [Marchiafava-Micheli]

The symptoms of paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] can vary from person to person, but some common symptoms include:

1. Dark urine
2. Weakness and fatigue
3. Shortness of breath
4. Paleness of skin
5. Chest pain
6. Abdominal pain

Causes of Paroxysmal Nocturnal Hemoglobinuria [Marchiafava-Micheli]

Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] is caused by a mutation in the PIGA gene. This gene is responsible for producing a protein that helps anchor certain proteins to the surface of red blood cells. Without this protein, the immune system mistakenly attacks and destroys the red blood cells, leading to anemia and other complications.

Diagnosis of Paroxysmal Nocturnal Hemoglobinuria [Marchiafava-Micheli]

Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] is diagnosed through a combination of medical history, physical examination, and laboratory tests. Some common tests used to diagnose this disorder include:

• Complete blood count (CBC)
• Flow cytometry
• Ham's test
• Bone marrow biopsy

Treatment of Paroxysmal Nocturnal Hemoglobinuria [Marchiafava-Micheli]

There is currently no cure for paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]. However, there are several treatments available to manage the symptoms and complications of this disorder. Some common treatments include:

• Blood transfusions
• Anticoagulant therapy
• Immunosuppressive therapy
• Bone marrow transplant

Conclusion

Paroxysmal nocturnal hemoglobinuria [Marchiafava-M