Progressive external ophthalmoplegia, bilateral Save

Understanding Progressive External Ophthalmoplegia, Bilateral

Progressive External Ophthalmoplegia, Bilateral (PEOB) is a rare genetic disorder that affects the muscles that control eye movement. It is a type of mitochondrial myopathy which leads to progressive weakness of the extraocular muscles, resulting in drooping of the eyelids and difficulty moving the eyes.

The onset of PEOB usually occurs in adulthood, typically between the ages of 18 and 40. The symptoms may begin gradually with mild ptosis (drooping of the eyelid) or diplopia (double vision) that worsens over time. The condition can also cause a variety of other symptoms, including weakness in other muscles, difficulty swallowing, and respiratory problems.

PEOB is caused by mutations in mitochondrial genes. Mitochondria are the powerhouses of cells, responsible for producing energy. When the mitochondria are not functioning properly, cells cannot produce enough energy to function correctly, leading to muscle weakness and other symptoms.

1. PEOB is a genetic disorder caused by mutations in mitochondrial genes
2. The condition affects the muscles that control eye movement, leading to drooping of the eyelids and difficulty moving the eyes
3. PEOB usually begins in adulthood, typically between the ages of 18 and 40
4. The symptoms may worsen over time and can also cause weakness in other muscles, difficulty swallowing, and respiratory problems

Diagnosis of PEOB involves a thorough physical examination, including an eye exam to assess eye movement and muscle strength. Genetic testing may also be done to confirm the diagnosis. Treatment of PEOB is focused on managing the symptoms and may include medications to improve muscle strength, physical therapy, and surgery in some cases.

In conclusion, Progressive External Ophthalmoplegia, Bilateral is a rare genetic disorder that affects the muscles that control eye movement. It is caused by mutations in mitochondrial genes and can lead to drooping of the eyelids and difficulty moving the eyes. While there is no cure for PEOB, treatment is available to manage the symptoms and improve quality of life.