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Toxic Epidermal Necrolysis [Lyell]: Causes, Symptoms, and Complications

Toxic Epidermal Necrolysis (TEN), also known as Lyell's syndrome, is a severe and potentially life-threatening skin condition. It is characterized by widespread skin detachment and mucosal involvement. Although rare, TEN requires immediate medical attention due to its high mortality rate. In this article, we will explore the causes, symptoms, and complications associated with this condition.

1. Causes:

TEN is often triggered by an adverse drug reaction, especially to certain medications like antibiotics, anticonvulsants, and nonsteroidal anti-inflammatory drugs (NSAIDs). Other causes may include infections, vaccines, malignancies, and autoimmune diseases. However, drug reactions remain the most common cause of TEN.

2. Symptoms:

The initial symptoms of TEN are often non-specific and may include fever, sore throat, cough, and flu-like symptoms. Within a few days, the skin starts to blister and detach, leading to painful, widespread areas of skin sloughing. The mucous membranes, such as the mouth, eyes, and genitals, may also be affected, causing discomfort and complications.

3. Complications:

TEN can lead to various complications, some of which can be life-threatening:

• Secondary infections: The compromised skin barrier makes individuals with TEN susceptible to bacterial, viral, and fungal infections.
• Fluid and electrolyte imbalances: The extensive skin loss can result in significant fluid and electrolyte disturbances, requiring close monitoring and management.
• Organ damage: In severe cases, TEN can affect internal organs, leading to complications such as liver dysfunction, kidney failure, and respiratory distress.
• Ocular complications: The involvement of the eyes can cause vision problems, corneal damage, and even blindness.
• Psychological impact: Patients with TEN may experience psychological distress, including anxiety and depression, due to the physical and emotional trauma associated with the condition.

Early diagnosis and prompt medical intervention are crucial in managing TEN. If you suspect you or someone you know may have TEN, seek immediate medical attention to minimize the risk of complications and improve the chances of recovery. Please note that this article does not provide information about treatment options, as they should only be determined by medical professionals.

In conclusion, Toxic Epidermal Necrolysis [Lyell] is a severe skin condition primarily triggered by adverse drug reactions. Its symptoms range from flu-like symptoms to widespread skin detachment, affecting mucous membranes as well. Complications can be

Treatment of Toxic epidermal necrolysis [Lyell]:

Treatment Options for Toxic Epidermal Necrolysis [Lyell]

Toxic Epidermal Necrolysis (TEN), also known as Lyell's Syndrome, is a severe and life-threatening skin disorder characterized by widespread skin detachment and mucous membrane involvement. Prompt and appropriate treatment is crucial to improve patient outcomes and reduce mortality rates.

1. Immediate Hos...

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