Von Willebrand's disease digital illustration

Von Willebrand's disease Save


ICD-10 code: D68.0

Disease category: D68: Other coagulation defects

Von Willebrand's disease: Overview

Von Willebrand's disease (VWD) is a bleeding disorder that affects the ability of the blood to clot. It is caused by a deficiency or dysfunction of the von Willebrand factor (VWF), a protein that plays an important role in blood clotting. VWD is a genetic disorder, which means it is passed down from parents to children.

Symptoms of Von Willebrand's disease

The most common symptom of VWD is bleeding, which can occur spontaneously or after an injury or surgery. The severity of bleeding can vary from mild to severe, and can affect different parts of the body, such as the nose, gums, skin, and joints. Women with VWD may experience heavy menstrual bleeding, which can lead to anemia.

Types of Von Willebrand's disease

There are three types of VWD:

  1. Type 1: This is the mildest form of VWD and is characterized by a partial deficiency of VWF. Symptoms are usually mild and may not be noticeable until an injury or surgery occurs.
  2. Type 2: This form of VWD is caused by a qualitative defect in VWF and is further divided into four subtypes (2A, 2B, 2M, and 2N) based on the specific defect. Symptoms can range from mild to severe, depending on the subtype.
  3. Type 3: This is the most severe form of VWD and is characterized by a complete deficiency of VWF. Symptoms are usually severe and can occur spontaneously or after minor injuries.
Diagnosis of Von Willebrand's disease

Diagnosis of VWD involves a series of tests to measure the level and function of VWF in the blood. The tests may include:

  • Bleeding time test
  • VWF antigen test
  • VWF activity test
  • Factor VIII activity test
Conclusion

Von Willebrand's disease is a bleeding disorder caused by a deficiency or dysfunction of the von Willebrand factor. It is a genetic disorder that can be passed down from parents to children. The symptoms of VWD can vary from mild to severe and can affect different parts of the body. Diagnosis of VWD involves a series of tests to measure the level and function of VWF in the blood.

Treatment of Von Willebrand's disease:

Von Willebrand's Disease: Treatment Options

Von Willebrand's disease is an inherited bleeding disorder characterized by a deficiency or dysfunction of von Willebrand factor, a protein that plays a crucial role in blood clotting. People with this condition may experience symptoms such as easy bruising, prolonged bleeding, and nosebleeds. Fortunately, there are several treatment opti...

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