Diffuse follicle center lymphoma digital illustration

Diffuse follicle center lymphoma Save

ICD-10 code: C82.5

Chapter: Neoplasms

Understanding Diffuse Follicle Center Lymphoma

Diffuse Follicle Center Lymphoma (DFCL) is a type of non-Hodgkin's lymphoma that originates from the lymphatic system. DFCL is called "diffuse" because it affects multiple areas of the lymphatic system, whereas "follicle center" refers to the location in the lymph nodes where the cancerous cells originate from.

DFCL is a relatively rare type of lymphoma, accounting for only 10% of all non-Hodgkin's lymphoma cases. It typically affects adults in their mid to late 60s, and there is a slightly higher incidence in men than women.

Symptoms of DFCL

The symptoms of DFCL can vary depending on the location and extent of the cancer. Common symptoms include:

  1. Swollen lymph nodes in the neck, armpits, or groin
  2. Fever
  3. Night sweats
  4. Unintentional weight loss
  5. Fatigue

Less commonly, DFCL can cause symptoms related to the affected organs, such as abdominal pain or shortness of breath.

Diagnosis and Treatment

DFCL is typically diagnosed through a combination of physical exams, blood tests, imaging tests, and biopsies. Once diagnosed, treatment options may include:

  1. Chemotherapy: the use of drugs to kill cancer cells
  2. Radiotherapy: the use of high-energy radiation to kill cancer cells
  3. Immunotherapy: the use of drugs to help the patient's immune system fight the cancer
  4. Stem cell transplant: replacing the patient's diseased bone marrow with healthy stem cells

The choice of treatment depends on the extent of the cancer and the patient's overall health. In some cases, a watch-and-wait approach may be recommended if the cancer is slow-growing and not causing symptoms.


Diffuse Follicle Center Lymphoma is a rare type of non-Hodgkin's lymphoma that originates from the lymphatic system. Symptoms include swollen lymph nodes, fever, night sweats, unintentional weight loss, and fatigue. Treatment options include chemotherapy, radiotherapy, immunotherapy, and stem cell transplant. If you experience any symptoms of DFCL, it is important to see a doctor for prompt diagnosis and treatment.