Anaplastic large cell lymphoma, ALK-negative, extranodal and solid organ sites Save

Anaplastic Large Cell Lymphoma, ALK-Negative, Extranodal And Solid Organ Sites

Anaplastic large cell lymphoma (ALCL) is an aggressive type of non-Hodgkin’s lymphoma (NHL). It is characterized by rapidly growing tumors, usually in the lymph nodes, skin, and soft tissues. ALCL can also be found in extranodal and solid organ sites, such as the lungs, skin, and gastrointestinal tract.

ALK-negative ALCL is a subtype of ALCL which is not affected by anaplastic lymphoma kinase (ALK). It is the most common form of ALCL and affects both adults and children. It is more aggressive than ALK-positive ALCL and is more likely to spread to other parts of the body.

ALCL usually presents in extranodal sites, including the skin, lungs, and gastrointestinal tract. In some cases, it can also affect solid organs, such as the liver, spleen, and kidneys. It is important to note that ALCL can spread to other organs, even if it is not present in the initial site.

The symptoms of ALCL vary and depend on the location of the tumor. Common symptoms include swelling and pain in the affected area, weight loss, fatigue, and fever. The diagnosis of ALCL is made with a biopsy, imaging tests, and laboratory tests. A combination of chemotherapy and radiation therapy is usually used to treat ALCL.

In conclusion, ALK-negative ALCL is an aggressive type of NHL which can present in extranodal and solid organ sites. It is important to recognize the symptoms and seek medical attention as soon as possible. Early diagnosis and treatment are essential for successful treatment and management of ALCL.