Anaplastic large cell lymphoma, ALK-positive, lymph nodes of inguinal region and lower limb Save

Anaplastic Large Cell Lymphoma, ALK-Positive, Lymph Nodes of Inguinal Region and Lower Limb

Anaplastic Large Cell Lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma that affects the lymphatic system. ALCL can occur in various parts of the body, including the lymph nodes, skin, bones, and soft tissues. However, when it affects the lymph nodes of the inguinal region and lower limb, it can cause specific symptoms and require specific diagnostic approaches.

ALK-positive ALCL is a subtype of ALCL that is characterized by the expression of a protein called anaplastic lymphoma kinase (ALK). This subtype accounts for approximately 20% of all cases of ALCL and tends to affect younger patients. ALK-positive ALCL can present as a localized or systemic disease and can involve lymph nodes in various parts of the body.

When ALK-positive ALCL affects the lymph nodes of the inguinal region and lower limb, it can cause symptoms such as swelling, pain, and discomfort in the affected area. The swelling may be unilateral or bilateral and can be accompanied by skin redness or warmth. In some cases, ALK-positive ALCL can also cause fever, night sweats, and weight loss, but these symptoms are not specific to this subtype of ALCL.

The diagnosis of ALK-positive ALCL involves a combination of imaging studies, such as ultrasound or CT scan, and biopsy of the affected lymph node or tissue. The biopsy allows the pathologist to examine the cells under a microscope and determine whether they have the characteristic features of ALCL, such as large, abnormal cells with horseshoe-shaped nuclei.

In conclusion, ALK-positive ALCL affecting the lymph nodes of the inguinal region and lower limb is a rare subtype of non-Hodgkin lymphoma that can cause specific symptoms and require specific diagnostic approaches. If you experience persistent swelling, pain, or discomfort in the groin area or lower limb, it is essential to seek medical attention to determine the underlying cause and receive appropriate treatment.

1. References:
2. Anaplastic Large Cell Lymphoma, ALK-Positive. Lymphoma Research Foundation. Available at: https://lymphoma.org/aboutlymphoma/nhl/alcl-alk-positive/
3. Levy, M.Y. (2020). Anaplastic Large Cell Lymphoma. Medscape. Available at: https://emedicine.medscape.com/article/203399-overview