Anaplastic large cell lymphoma, ALK-positive digital illustration

Anaplastic large cell lymphoma, ALK-positive Save

ICD-10 code: C84.6

Chapter: Neoplasms

Anaplastic large cell lymphoma, ALK-positive: Symptoms, Diagnosis, and Treatment

Anaplastic large cell lymphoma, ALK-positive (ALCL) is a rare type of non-Hodgkin lymphoma that affects the immune system. It is called ALK-positive because it is characterized by the presence of a mutated protein called anaplastic lymphoma kinase (ALK) on the surface of the cancerous cells. This protein is not found in healthy cells, which makes it a good target for treatment.

ALCL can occur in people of any age, but it is more common in children and young adults. The symptoms of ALCL can vary depending on the location of the cancer, but they often include:

  1. Swollen lymph nodes
  2. Fever
  3. Night sweats
  4. Weight loss
  5. Fatigue

If you are experiencing any of these symptoms, it is important to see a doctor as soon as possible. Your doctor may perform a physical exam, blood tests, and imaging tests such as X-rays, CT scans, or PET scans to help diagnose ALCL.

The most effective treatment for ALCL depends on the stage of the cancer and other factors such as your age and overall health. Treatment options may include:

  1. Chemotherapy
  2. Radiation therapy
  3. Stem cell transplant
  4. Targeted therapy

Targeted therapy is a type of treatment that targets specific proteins or other molecules that are involved in the growth and spread of cancer cells. In the case of ALCL, targeted therapy may involve drugs that specifically target the ALK protein.

ALCL is a rare cancer, but it is important to be aware of its symptoms and to seek medical attention if you are experiencing any of them. Early diagnosis and treatment can improve your chances of a successful outcome.