Corneal deposits in metabolic disorders, unspecified eye Save

Understanding Corneal Deposits in Metabolic Disorders

Corneal deposits are a common symptom of metabolic disorders, a group of conditions that affect the body's ability to process and use nutrients. These deposits can cause cloudiness or opacity in the cornea, the clear outer layer of the eye that covers the iris and pupil.

While corneal deposits can occur in a variety of metabolic disorders, they are commonly associated with conditions such as diabetes, Wilson's disease, and Fabry disease. These disorders can cause the buildup of abnormal proteins or lipids in the cornea, which can lead to the formation of deposits over time.

1. Diabetes: People with diabetes may develop corneal deposits due to high blood sugar levels, which can cause the accumulation of sorbitol in the cornea. Sorbitol is a sugar alcohol that can lead to the formation of protein deposits in the eye.
2. Wilson's Disease: This rare genetic disorder causes the accumulation of copper in various organs, including the eyes. In the cornea, copper deposits can cause a characteristic brown or green ring around the iris.
3. Fabry Disease: This inherited disorder affects the body's ability to break down a type of fat called globotriaosylceramide (Gb3). Gb3 can accumulate in the cornea and other organs, leading to the formation of deposits.

Other metabolic disorders that can cause corneal deposits include mucopolysaccharidoses, lipidoses, and porphyrias. In some cases, corneal deposits may be a sign of an undiagnosed metabolic disorder, so it's important to see an eye doctor if you notice any changes in your vision or the appearance of your eyes.

While corneal deposits themselves are not typically harmful to the eye, they can cause vision problems if they interfere with the passage of light through the cornea. Treatment for corneal deposits in metabolic disorders varies depending on the underlying condition, but may include medications to reduce the accumulation of abnormal substances or corneal transplant surgery in severe cases.